The Schistosoma mansoni Tegumental-Allergen-Like (TAL) Protein Family: Influence of Developmental Expression on Human IgE Responses

@inproceedings{Fitzsimmons2012TheSM,
  title={The Schistosoma mansoni Tegumental-Allergen-Like (TAL) Protein Family: Influence of Developmental Expression on Human IgE Responses},
  author={Colin M. Fitzsimmons and Frances M. Jones and Alex Stearn and Iain W. Chalmers and Karl F. Hoffmann and Jakub M. Wawrzyniak and Shona Wilson and Narcis B. Kabatereine and David W. Dunne},
  booktitle={PLoS neglected tropical diseases},
  year={2012}
}
BACKGROUND A human IgE response to Sm22.6 (a dominant IgE target in Schistosoma mansoni) is associated with the development of partial immunity. Located inside the tegument, the molecule belongs to a family of proteins from parasitic platyhelminths, the Tegument-Allergen-Like proteins (TALs). In addition to containing dynein-light-chain domains, these TALs also contain EF-hand domains similar to those found in numerous EF-hand allergens. METHODOLOGY/PRINCIPAL FINDINGS S. mansoni genome… CONTINUE READING
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Analysis of complex patterns of human exposure and immunity to Schistosomiasis mansoni: the influence of age, sex, ethnicity and IgE

  • A Pinot de Moira, AJ Fulford, NB Kabatereine, JH Ouma, M Booth
  • PLoS Negl Trop Dis
  • 2010
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