The Sch9 kinase is a chromatin-associated transcriptional activator of osmostress-responsive genes.

@article{PascualAhuir2007TheSK,
  title={The Sch9 kinase is a chromatin-associated transcriptional activator of osmostress-responsive genes.},
  author={Amparo Pascual-Ahuir and Markus Proft},
  journal={The EMBO journal},
  year={2007},
  volume={26 13},
  pages={3098-108}
}
The yeast Sch9 kinase has been implicated in the cellular adjustment to nutrient availability and in the regulation of aging. Here, we define a novel role for Sch9 in the transcriptional activation of osmostress inducible genes. Loss-of-function mutants sch9 are sensitive to hyperosmotic stress and show an impaired transcriptional response upon osmotic shock of several defense genes. We show that Sch9 is required for gene expression regulated by Sko1, a transcription factor, which is directly… CONTINUE READING
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