The Scc2/Scc4 cohesin loader determines the distribution of cohesin on budding yeast chromosomes.

@article{Kogut2009TheSC,
  title={The Scc2/Scc4 cohesin loader determines the distribution of cohesin on budding yeast chromosomes.},
  author={Igor Kogut and Jianbin Wang and Vincent Anthony Guacci and Rohinton K Mistry and Paul C. Megee},
  journal={Genes & development},
  year={2009},
  volume={23 19},
  pages={2345-57}
}
Cohesins mediate sister chromatid cohesion and DNA repair and also function in gene regulation. Chromosomal cohesins are distributed nonrandomly, and their deposition requires the heterodimeric Scc2/Scc4 loader. Whether Scc2/Scc4 establishes nonrandom cohesin distributions on chromosomes is poorly characterized, however. To better understand the spatial… CONTINUE READING