The Satb1 protein directs hematopoietic stem cell differentiation toward lymphoid lineages.

@article{Satoh2013TheSP,
  title={The Satb1 protein directs hematopoietic stem cell differentiation toward lymphoid lineages.},
  author={Yusuke Satoh and Takafumi Yokota and Takao Sudo and Motonari Kondo and Anne Y. Lai and Paul W. Kincade and Taku Kouro and Ryuji Iida and Koichi Kokame and Toshiyuki Miyata and Yoko Habuchi and Keiko Matsui and Hirokazu Tanaka and Itaru Matsumura and Kenji Oritani and Terumi Kohwi-Shigematsu and Yuzuru Kanakura},
  journal={Immunity},
  year={2013},
  volume={38 6},
  pages={1105-15}
}
How hematopoietic stem cells (HSCs) produce particular lineages is insufficiently understood. We searched for key factors that direct HSC to lymphopoiesis. Comparing gene expression profiles for HSCs and early lymphoid progenitors revealed that Satb1, a global chromatin regulator, was markedly induced with lymphoid lineage specification. HSCs from Satb1-deficient mice were defective in lymphopoietic activity in culture and failed to reconstitute T lymphopoiesis in wild-type recipients… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 9 times over the past 90 days. VIEW TWEETS