The Salmonella YopJ-homologue AvrA does not possess YopJ-like activity.

  title={The Salmonella YopJ-homologue AvrA does not possess YopJ-like activity.},
  author={Kurt Schesser and J M Dukuzumuremyi and Corrado Cilio and S\oren Borg and Timothy S. Wallis and Sven Pettersson and Edouard E. Galyov},
  journal={Microbial pathogenesis},
  volume={28 2},
The YopJ protein of Yersinia pseudotuberculosis inhibits several eukaryotic signalling pathways that are normally activated in cells following their contact with bacteria. Salmonella encodes a protein, AvrA, that is secreted by the typeIII inv/spa secretion system which is clearly homologous to YopJ (56% identical, 87% similarity). Since AvrA and YopJs similarity also encompassed a region of YopJ that had previously been shown to be critical for its biological activity, we were interested… CONTINUE READING


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