The Sak polo-box comprises a structural domain sufficient for mitotic subcellular localization

@article{Leung2002TheSP,
  title={The Sak polo-box comprises a structural domain sufficient for mitotic subcellular localization},
  author={Genie C. Leung and John W. Hudson and Anna Kozarova and Alan Davidson and J. W. Dennis and Frank Sicheri},
  journal={Nature Structural Biology},
  year={2002},
  volume={9},
  pages={719-724}
}
The small family of polo-like kinases (Plks) includes Cdc5 from Saccharomyces cerevisiae, Plo1 from Schizosaccharomyces pombe, Polo from Drosophila melanogaster and the four mammalian genes Plk1, Prk/Fnk, Snk and Sak. These kinases control cell cycle progression through the regulation of centrosome maturation and separation, mitotic entry, metaphase to anaphase transition, mitotic exit and cytokinesis. Plks are characterized by an N-terminal Ser/Thr protein kinase domain and the presence of one… CONTINUE READING
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