The Saitohin 'Q7R' polymorphism and tau haplotype in multi-ethnic Alzheimer disease and Parkinson's disease cohorts.

@article{Clark2003TheS,
  title={The Saitohin 'Q7R' polymorphism and tau haplotype in multi-ethnic Alzheimer disease and Parkinson's disease cohorts.},
  author={Lorraine N. Clark and Gilberto Levy and M. Tang and Helen Mejia-Santana and Alejandra Ciappa and Benjamin Tycko and Lucien J. Cot{\'e} and Elan Daniel Louis and Richard P. Mayeux and Karen S. Marder},
  journal={Neuroscience letters},
  year={2003},
  volume={347 1},
  pages={17-20}
}
In a multi-ethnic cohort we analyzed the Saitohin (STH) gene 'Q7R' polymorphism in 200 late-onset Alzheimer's disease cases (LOAD), 60 Parkinson's disease cases with dementia (PDD), 84 Parkinson's disease cases without dementia and 458 controls. We found no significant differences in genotype or allele frequencies when LOAD or PD cases were compared to controls. Ethnic differences in STH genotype frequencies for cases and controls were observed and these were statistically significant (cases n… CONTINUE READING
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