The Safety of Newer Antidepressants in Pregnancy and Breastfeeding

@article{Gentile2005TheSO,
  title={The Safety of Newer Antidepressants in Pregnancy and Breastfeeding},
  author={Salvatore Gentile},
  journal={Drug Safety},
  year={2005},
  volume={28},
  pages={137-152}
}
  • S. Gentile
  • Published 2005
  • Medicine, Psychology
  • Drug Safety
The pregnancy and postpartum periods are considered to be relatively high risk times for depressive episodes in women, particularly for those with pre-existing psychiatric illnesses. Therefore, it may be necessary to start or continue the pharmacological treatment of depression during these two timeframes. Hence, the aim of this review is to examine the effects on the fetus and infant of exposure, through the placenta and maternal milk, to the following drugs: fluoxetine, fluvoxamine… 
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TLDR
In accordance with the Breastfed Infant-Antidepressant Safety Index classification, sertraline and paroxetine should be considered as first-line medications in women who need to start antidepressant treatment during the postpartum period and wish to continue breastfeeding.
Psychopharmacotherapy in Pregnancy and Breastfeeding
TLDR
The learner should be better able to identify the main categories of psychiatric drugs used during pregnancy and breastfeeding, discuss side effects for the mother and the newborn associated with these drugs, and use the most appropriate drug according to different clinical situations.
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  • S. Gentile
  • Medicine, Psychology
    Current opinion in psychiatry
  • 2011
TLDR
Avoiding the use of clorimipramine, paroxetine, valproate, and atypical antipsychotics during pregnancy is advisable, however, when starting or continuing pharmacological treatment during pregnancy, clinicians should consider not only the intrinsic iatrogenic risk of birth defects or perinatal complications, but also the general safety profile for the expectant mother.
Prophylactic treatment of bipolar disorder in pregnancy and breastfeeding: focus on emerging mood stabilizers.
  • S. Gentile
  • Medicine, Psychology
    Bipolar disorders
  • 2006
TLDR
This review compares information from the literature on the safety of lamotrigine, oxcarbazepine, risperidone, olanzapine, and quetiapine to the safety data on classic mood stabilizers during pregnancy and the postpartum period to suggest thatUntreated pregnant bipolar women are at an increased risk of poor obstetrical outcomes and relapse of affective symptoms.
Use of Antidepressants to Treat Postpartum Depression, During Breast Feeding
TLDR
Studies are needed with larger samples to properly evaluate the short and long-term effects of antidepressants on infants exposed through breast milk, so that clinicians can create standard decisions regarding the treatment of postpartum depression, without putting infants at risk.
Maternal use of SSRIs, SNRIs and NaSSAs: practical recommendations during pregnancy and lactation
TLDR
Limited data are available about the long-term neurodevelopmental outcomes after SSRI exposure during pregnancy and lactation, but currently, cognitive development seems normal, while behavioural abnormalities may be increased.
Pharmacological Aspects of Neonatal Antidepressant Withdrawal
TLDR
The reader should be able to explain the importance of antidepressant therapy during pregnancy and postpartum, summarize the important neonatal effects of antidepressants, and describe the potential teratogenic effects ofidepressants.
The use of psychotropic medication during pregnancy: how about the newborn?
TLDR
Infants are at risk of developing symptoms of Poor Neonatal Adaptation after exposure to psychotropic drugs in utero, breastfeeding is presumably protective for development of PNA, and Phenobarbital is a safe therapeutic option.
Breastfeeding and antidepressants.
  • T. Field
  • Psychology, Medicine
    Infant behavior & development
  • 2008
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