The Saccharomyces cerevisiae phosphatase activator RRD1 is required to modulate gene expression in response to rapamycin exposure.

@article{Douville2006TheSC,
  title={The Saccharomyces cerevisiae phosphatase activator RRD1 is required to modulate gene expression in response to rapamycin exposure.},
  author={Julie Douville and Jocelyn David and Karine M Lemieux and Luc Gaudreau and Dindial Ramotar},
  journal={Genetics},
  year={2006},
  volume={172 2},
  pages={1369-72}
}
We show that mutants lacking either the phosphatase activator Rrd1 or the phosphatase Pph3 are resistant to rapamycin and that double mutants exhibit a synergistic response. This phenotype could be related to an inability of the mutants to degrade RNA polymerase II, leading to transcription of critical genes that sustain growth. 

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