The Saccharomyces cerevisiae YBR159w gene encodes the 3-ketoreductase of the microsomal fatty acid elongase.

@article{Han2002TheSC,
  title={The Saccharomyces cerevisiae YBR159w gene encodes the 3-ketoreductase of the microsomal fatty acid elongase.},
  author={Gongshe Han and Ken Gable and Sepp D. Kohlwein and Fr{\'e}d{\'e}ric Beaudoin and Johnathan A Napier and Teresa M. Dunn},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 38},
  pages={35440-9}
}
The YBR159w gene encodes the major 3-ketoreductase activity of the elongase system of enzymes required for very long-chain fatty acid (VLCFA) synthesis. Mutants lacking the YBR159w gene display many of the phenotypes that have previously been described for mutants with defects in fatty acid elongation. These phenotypes include reduced VLCFA synthesis, accumulation of high levels of dihydrosphingosine and phytosphingosine, and accumulation of medium-chain ceramides. In vitro elongation assays… CONTINUE READING