The Saccharomyces cerevisiae RTG2 gene is a regulator of aconitase expression under catabolite repression conditions.

@article{Vlot1996TheSC,
  title={The Saccharomyces cerevisiae RTG2 gene is a regulator of aconitase expression under catabolite repression conditions.},
  author={Christian V{\'e}lot and Peter Haviernik and Guy J-M Lauquin},
  journal={Genetics},
  year={1996},
  volume={144 3},
  pages={893-903}
}
The ACO1 gene, encoding mitochondrial aconitase of Saccharomyces cerevisiae, is required both for oxidative metabolism and for glutamate prototrophy. This gene is subject to catabolite repression; the ACOI mRNA level is further reduced when glutamate is supplied with glucose. To further explore regulation of ACOI expression, we have screened for mutations that reduce expression of an ACOI-lacZ fusion borne on a multicopy vector. We identified a gene required for wild-type expression of ACOI… CONTINUE READING