The Saccharomyces cerevisiae MUM2 gene interacts with the DNA replication machinery and is required for meiotic levels of double strand breaks.

@article{Davis2001TheSC,
  title={The Saccharomyces cerevisiae MUM2 gene interacts with the DNA replication machinery and is required for meiotic levels of double strand breaks.},
  author={Luther Davis and Mariagnese Barbera and Amanda McDonnell and Katherine McIntyre and Rolf Sternglanz and Quan-wen Jin and Josef Loidl and JoAnne Engebrecht},
  journal={Genetics},
  year={2001},
  volume={157 3},
  pages={1179-89}
}
The Saccharomyces cerevisiae MUM2 gene is essential for meiotic, but not mitotic, DNA replication and thus sporulation. Genetic interactions between MUM2 and a component of the origin recognition complex and polymerase alpha-primase suggest that MUM2 influences the function of the DNA replication machinery. Early meiotic gene expression is induced to a much greater extent in mum2 cells than in meiotic cells treated with the DNA synthesis inhibitor hydroxyurea. This result indicates that the… CONTINUE READING
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