The Sac3 homologue shd1 is involved in mitotic progression in mammalian cells.

@article{Khuda2004TheSH,
  title={The Sac3 homologue shd1 is involved in mitotic progression in mammalian cells.},
  author={Sefat-E- Khuda and Mikoto Yoshida and Yan Xing and Tatsuya Shimasaki and Motohiro Takeya and Kazuhiko Kuwahara and Nobuo Sakaguchi},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 44},
  pages={46182-90}
}
Saccharomyces Sac3 required for actin assembly was shown to be involved in DNA replication. Here, we studied the function of a mammalian homologue SHD1 in cell cycle progression. SHD1 is localized on centrosomes at interphase and at spindle poles and mitotic spindles, similar to alpha-tubulin, at M phase. RNA interference suppression of endogenous shd1 caused defects in centrosome duplication and spindle formation displaying cells with a single apparent centrosome and down-regulated Mad2… CONTINUE READING