The SUMOylation Pathway Restricts Gene Transduction by Adeno-Associated Viruses

Abstract

Adeno-associated viruses are members of the genus dependoviruses of the parvoviridae family. AAV vectors are considered promising vectors for gene therapy and genetic vaccination as they can be easily produced, are highly stable and non-pathogenic. Nevertheless, transduction of cells in vitro and in vivo by AAV in the absence of a helper virus is… (More)
DOI: 10.1371/journal.ppat.1005281

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