The SUMO E3-ligase PIAS1 regulates the tumor suppressor PML and its oncogenic counterpart PML-RARA.

@article{Rabellino2012TheSE,
  title={The SUMO E3-ligase PIAS1 regulates the tumor suppressor PML and its oncogenic counterpart PML-RARA.},
  author={Andrea Rabellino and Brandon S. Carter and Georgia Konstantinidou and S Wu and Alessandro Rimessi and Lauren A. Byers and John V. Heymach and Luc Girard and C. -S. Chiang and Julie Teruya-Feldstein and Pier Paolo Scaglioni},
  journal={Cancer research},
  year={2012},
  volume={72 9},
  pages={2275-84}
}
The ubiquitin-like SUMO proteins covalently modify protein substrates and regulate their functional properties. In a broad spectrum of cancers, the tumor suppressor PML undergoes ubiquitin-mediated degradation primed by CK2 phosphorylation. Here, we report that the SUMO E3-ligase inhibitor PIAS1 regulates oncogenic signaling through its ability to sumoylate PML and the PML-RARA oncoprotein of acute promyelocytic leukemia (APL). PIAS1-mediated SUMOylation of PML promoted CK2 interaction and… CONTINUE READING