The STATs of cancer — new molecular targets come of age

@article{Yu2004TheSO,
  title={The STATs of cancer — new molecular targets come of age},
  author={Hua Yu and Richard Jove},
  journal={Nature Reviews Cancer},
  year={2004},
  volume={4},
  pages={97-105}
}
Tumour cells acquire the ability to proliferate uncontrollably, resist apoptosis, sustain angiogenesis and evade immune surveillance. STAT proteins — especially STAT3 and STAT5 — regulate all of these processes and are persistently activated in a surprisingly large number of human cancers. Consequently, STAT proteins are emerging — unexpectedly — as ideal… CONTINUE READING