The STAT3 pathway as a therapeutic target in head and neck cancer: Barriers and innovations.

@article{Geiger2016TheSP,
  title={The STAT3 pathway as a therapeutic target in head and neck cancer: Barriers and innovations.},
  author={Jessica L. Geiger and Jennifer R Grandis and J. E. Jun. Bauman},
  journal={Oral oncology},
  year={2016},
  volume={56},
  pages={
          84-92
        }
}
Proteins of the signal transducer and activator of transcription (STAT) family mediate cellular responses to cytokines and growth factors. Aberrant regulation of the STAT3 oncogene contributes to tumor formation and progression in many cancers, including head and neck squamous cell carcinoma (HNSCC), where hyperactivation of STAT3 is implicated in both treatment resistance and immune escape. There are no oncogenic gain-of-function mutations in HNSCC. Rather, aberrant STAT3 signaling is… CONTINUE READING
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