The SREBP pathway — insights from insigs and insects

@article{Rawson2003TheSP,
  title={The SREBP pathway — insights from insigs and insects},
  author={R. Rawson},
  journal={Nature Reviews Molecular Cell Biology},
  year={2003},
  volume={4},
  pages={631-640}
}
  • R. Rawson
  • Published 2003
  • Chemistry, Medicine, Biology
  • Nature Reviews Molecular Cell Biology
  • Animal cells coordinate lipid homeostasis by end-product feedback regulation of transcription. The control occurs through the proteolytic release of transcriptionally active sterol regulatory element binding proteins (SREBPs) from intracellular membranes. This feedback system has unexpected features that are found in all cells. Here, we consider recently discovered components of the regulatory machinery that govern SREBP processing, as well as studies in Drosophila that indicate an ancient role… CONTINUE READING
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    References

    SHOWING 1-10 OF 93 REFERENCES
    SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver.
    • 3,759
    • PDF
    Regulation of the mevalonate pathway
    • 4,757
    • PDF