The SREBP pathway — insights from insigs and insects

  title={The SREBP pathway — insights from insigs and insects},
  author={Robert B. Rawson},
  journal={Nature Reviews Molecular Cell Biology},
  • R. B. Rawson
  • Published 1 August 2003
  • Biology
  • Nature Reviews Molecular Cell Biology
Animal cells coordinate lipid homeostasis by end-product feedback regulation of transcription. The control occurs through the proteolytic release of transcriptionally active sterol regulatory element binding proteins (SREBPs) from intracellular membranes. This feedback system has unexpected features that are found in all cells. Here, we consider recently discovered components of the regulatory machinery that govern SREBP processing, as well as studies in Drosophila that indicate an ancient role… 

SREBP in signal transduction: cholesterol metabolism and beyond.

Evolutionary conservation and adaptation in the mechanism that regulates SREBP action: what a long, strange tRIP it's been.

This review integrates classic features of the SREBP pathway with newer information regarding the regulation and sensing mechanisms that serve to assimilate different cellular physiologic processes for optimal function and growth.

SREBPs: sterol-regulated transcription factors.

Studies of the feedback regulation of cholesterol synthesis in animals have led to the identification of a unique family of membrane-bound transcription factors, sterol regulatory element binding

Regulation of sterol synthesis in eukaryotes.

A comparative analysis of SREBP and HMG-CoA reductase regulation in mammals, yeast, and flies points toward an equilibrium model for how lipid signals regulate the activity of sterol-sensing proteins and their downstream effectors.

SREBPs: physiology and pathophysiology of the SREBP family

The pathological aspects of SREBPs are discussed, which contribute to lipotoxicity in a wide variety of organs, including hepatic insulin resistance in hepatosteatosis, impaired insulin secretion in pancreatic β‐cells, diabetic nephropathy, cardiac arrythmiasis, and obesity.

Endoplasmic reticulum stress and lipid dysregulation

This review will provide an overview of ER stress and the UPR as well as cholesterol homeostasis and SREBP regulation, with an emphasis on their interaction and biological relevance.

Effects of sterol regulatory element-binding protein (SREBP) in chickens

A prelude to the investigation of the role of SREBP in lipid metabolism regulation in chicken, a review of Size and Tissue expression Pattern of S REBP and role of this protein in chickens is reviewed.

Lipid Signaling and Homeostasis: PA- Is Better than PA-H, But What About Those PIPs?

New work indicates that regulation of intracellular pH levels in yeast by glucose availability may fine-tune the binding of the repressor to its lipid ligand, providing a mechanism that connects phospholipid metabolism to nutrient sensing.



Regulation of SREBP Processing and Membrane Lipid Production by Phospholipids in Drosophila

The finding that SRE BP processing is controlled by different lipids in mammals and flies (sterols and phosphatidylethanolamine, respectively) suggests that an essential function of SREBP is to monitor cell membrane composition and to adjust lipid synthesis accordingly.

Sterol regulatory element-binding proteins: activators of cholesterol and fatty acid biosynthesis.

A family of transcription factors designated sterol regulatory element-binding proteins (SREBPs) mediates the previously described end-product feedback regulation of cholesterol biosynthesis. In

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver.

The complex, interdigitated roles of these three SREBPs have been dissected through the study of ten different lines of gene-manipulated mice and form the subject of this review.

Regulation of the mevalonate pathway

The mevalonate pathway produces isoprenoids that are vital for diverse cellular functions, ranging from cholesterol synthesis to growth control, and could be useful in treating certain forms of cancer as well as heart disease.

Mutant mammalian cells as tools to delineate the sterol regulatory element-binding protein pathway for feedback regulation of lipid synthesis.

The somatic cell genetic approach described in this article should prove useful for unraveling other complex biochemical pathways in animal cells.

HLH106, a Drosophila transcription factor with similarity to the vertebrate sterol responsive element binding protein.

A Drosophila homolog to the sterol responsive element binding proteins (SREBPs) is cloned, and it is found the full-length gene product in the membrane fraction and a shorter cross-reacting form in the nuclear fraction.