The SREBP Pathway: Regulation of Cholesterol Metabolism by Proteolysis of a Membrane-Bound Transcription Factor

@article{Brown1997TheSP,
  title={The SREBP Pathway: Regulation of Cholesterol Metabolism by Proteolysis of a Membrane-Bound Transcription Factor},
  author={Michael Scott Brown and Joseph L Goldstein},
  journal={Cell},
  year={1997},
  volume={89},
  pages={331-340}
}
biosynthetic pathway, thereby limiting the production Animal cells must regulate their biosynthetic pathways of cholesterol (reviewed in Goldstein and Brown, 1990). so as to produce the required amounts of end-products The importance of the cholesterol feedback system without risking overproduction. Such control is particuto human health was established by the finding that larly important in cholesterol homeostasis because chodiets rich in cholesterol and saturated fatty acids raise lesterol… CONTINUE READING
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