The SR Protein B52/SRp55 Is Required for DNA Topoisomerase I Recruitment to Chromatin, mRNA Release and Transcription Shutdown

@inproceedings{Juge2010TheSP,
  title={The SR Protein B52/SRp55 Is Required for DNA Topoisomerase I Recruitment to Chromatin, mRNA Release and Transcription Shutdown},
  author={François Juge and C{\'e}line Fernando and Weronika Fic and Jamal Tazi},
  booktitle={PLoS genetics},
  year={2010}
}
DNA- and RNA-processing pathways are integrated and interconnected in the eukaryotic nucleus to allow efficient gene expression and to maintain genomic stability. The recruitment of DNA Topoisomerase I (Topo I), an enzyme controlling DNA supercoiling and acting as a specific kinase for the SR-protein family of splicing factors, to highly transcribed loci represents a mechanism by which transcription and processing can be coordinated and genomic instability avoided. Here we show that Drosophila… CONTINUE READING
Highly Cited
This paper has 18 citations. REVIEW CITATIONS

From This Paper

Topics from this paper.
7 Citations
62 References
Similar Papers

References

Publications referenced by this paper.
Showing 1-10 of 62 references

Similar Papers

Loading similar papers…