The SPS amino acid sensor mediates nutrient acquisition and immune evasion in Candida albicans.

@article{Miramn2016TheSA,
  title={The SPS amino acid sensor mediates nutrient acquisition and immune evasion in Candida albicans.},
  author={Pedro Miram{\'o}n and Michael C Lorenz},
  journal={Cellular microbiology},
  year={2016},
  volume={18 11},
  pages={1611-1624}
}
Candida albicans is well adapted to its host and is able to sense and respond to the nutrients available within. We have shown that C. albicans avidly utilizes amino acids as a carbon source, which allows this opportunistic pathogen to neutralize acidic environments, including the macrophage phagosome. The transcription factor Stp2 is a key regulator of this phenomenon, and we sought to understand the mechanism of activation of Stp2, focusing on the SPS sensor system previously characterized… CONTINUE READING
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