The SPRY domain of Pyrin, mutated in familial Mediterranean fever patients, interacts with inflammasome components and inhibits proIL-1β processing

@article{Papin2007TheSD,
  title={The SPRY domain of Pyrin, mutated in familial Mediterranean fever patients, interacts with inflammasome components and inhibits proIL-1β processing},
  author={St{\'e}phanie Papin and Solange Cuenin and Laetitia Agostini and Fabio Martinon and S{\"o}ren Werner and H-D Beer and Christian Gruetter and Markus G. Gruetter and J. -M. Tschopp},
  journal={Cell Death and Differentiation},
  year={2007},
  volume={14},
  pages={1457-1466}
}
The autoinflammatory disorders Muckle–Wells syndrome, familial cold urtecaria and chronic infantile neurological cutaneous and articular syndrome are associated with mutations in the NALP3 (Cryopyrin) gene, which is the central platform of the proinflammatory caspase-1 activating complex, named the inflammasome. In patients with another autoinflammatory disorder, familial Mediterranean fever (FMF), mutations in the SPRY domain of the Pyrin protein are frequently found. Recent evidence suggests… CONTINUE READING

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The estrogenresponsive B box protein: a novel enhancer of interleukin-1beta secretion

  • C Munding, M Keller, G Niklaus, S Papin, J Tschopp, S Werner
  • Cell Death Differ
  • 2006
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