The SPA2 gene of Saccharomyces cerevisiae is important for pheromone- induced morphogenesis and efficient mating

@article{Gehrung1990TheSG,
  title={The SPA2 gene of Saccharomyces cerevisiae is important for pheromone- induced morphogenesis and efficient mating},
  author={Sonja Gehrung and Michael Snyder},
  journal={The Journal of Cell Biology},
  year={1990},
  volume={111},
  pages={1451 - 1464}
}
Upon exposure to mating pheromone, Saccharomyces cerevisiae undergoes cellular differentiation to form a morphologically distinct cell called a "shmoo". Double staining experiments revealed that both the SPA2 protein and actin localize to the shmoo tip which is the site of polarized cell growth. Actin concentrates as spots throughout the shmoo projection, while SPA2 localizes as a sharp patch at the shmoo tip. DNA sequence analysis of the SPA2 gene revealed an open reading frame 1,466 codons in… CONTINUE READING
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