The SOX17/miR-371-5p/SOX2 axis inhibits EMT, stem cell properties and metastasis in colorectal cancer

@inproceedings{Li2015TheSA,
  title={The SOX17/miR-371-5p/SOX2 axis inhibits EMT, stem cell properties and metastasis in colorectal cancer},
  author={Yuling Li and Zhenbing Lv and Guoyang He and Jianmei Wang and Xiaojing Zhang and Guifeng Lu and Xiaoli Ren and Feifei Wang and Xiaohui Zhu and Yi Ding and Wenting Liao and Yanqing Ding and Li Liang},
  booktitle={Oncotarget},
  year={2015}
}
Cancer stem cells (CSCs) and EMT-type cells, which share molecular characteristics with CSCs, have been believed to play critical roles in tumor metastasis. Although much progress has been garnered in elucidating the molecular pathways that trigger EMT, stemness and metastasis, a number of key mechanistic gaps remain elusive. In the study, miR-371-5p was obviously down-regulated in primary CRC tissues compared with matched adjacent normal mucosa and correlated significantly with differentiation… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS