The SOD mimetic tempol ameliorates glomerular injury and reduces mitogen-activated protein kinase activity in Dahl salt-sensitive rats.

@article{Nishiyama2004TheSM,
  title={The SOD mimetic tempol ameliorates glomerular injury and reduces mitogen-activated protein kinase activity in Dahl salt-sensitive rats.},
  author={Akira Nishiyama and Masanori Yoshizumi and Hirofumi Hitomi and Shoji Kagami and Shuji Kondo and Akira Miyatake and Megumu Fukunaga and Toshiaki Tamaki and Hideyasu Kiyomoto and Masakazu Kohno and Takatomi Shokoji and Shoji Kimura and Youichi Abe},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2004},
  volume={15 2},
  pages={306-15}
}
It was shown recently that renal injury in Dahl salt-sensitive (DS) hypertensive rats is accompanied by mitogen-activated protein kinase (MAPK) activation. The present study was conducted to elucidate the contribution of reactive oxygen species to MAPK activities and renal injury in DS rats. DS rats were maintained on high salt (H; 8.0% NaCl; n = 7) or low salt (L; 0.3% NaCl; n = 6) diets; H + a superoxide dismutase mimetic, tempol (3 mmol/L in drinking water; n = 8); or H + hydralazine (0.5… CONTINUE READING