The SNARE Ykt6 mediates protein palmitoylation during an early stage of homotypic vacuole fusion.

@article{Dietrich2004TheSY,
  title={The SNARE Ykt6 mediates protein palmitoylation during an early stage of homotypic vacuole fusion.},
  author={Lars E P Dietrich and Rolf Gurezka and Michael Veit and Christian Ungermann},
  journal={The EMBO journal},
  year={2004},
  volume={23 1},
  pages={45-53}
}
The NSF homolog Sec18 initiates fusion of yeast vacuoles by disassembling cis-SNARE complexes during priming. Sec18 is also required for palmitoylation of the fusion factor Vac8, although the acylation machinery has not been identified. Here we show that the SNARE Ykt6 mediates Vac8 palmitoylation and acts during a novel subreaction of vacuole fusion. This subreaction is controlled by a Sec17-independent function of Sec18. Our data indicate that Ykt6 presents Pal-CoA via its N-terminal longin… CONTINUE READING

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