The SNARE Machinery Is Involved in Apical Plasma Membrane Trafficking in MDCK Cells

  title={The SNARE Machinery Is Involved in Apical Plasma Membrane Trafficking in MDCK Cells },
  author={Seng Hui Low and Steven J. Chapin and Christian Wimmer and Sidney W Whiteheart and L{\'a}szl{\'o} G. K{\"o}m{\"u}ves and Keith E. Mostov and Thomas Weimbs},
  journal={The Journal of Cell Biology},
  pages={1503 - 1513}
We have investigated the controversial involvement of components of the SNARE (soluble N-ethyl maleimide-sensitive factor [NSF] attachment protein [SNAP] receptor) machinery in membrane traffic to the apical plasma membrane of polarized epithelial (MDCK) cells. Overexpression of syntaxin 3, but not of syntaxins 2 or 4, caused an inhibition of TGN to apical transport and apical recycling, and leads to an accumulation of small vesicles underneath the apical plasma membrane. All other tested… CONTINUE READING


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