The SNAP-25 gene may be associated with clinical response and weight gain in antipsychotic treatment of schizophrenia.

@article{Mller2005TheSG,
  title={The SNAP-25 gene may be associated with clinical response and weight gain in antipsychotic treatment of schizophrenia.},
  author={Daniel J M{\"u}ller and Tim A Klempan and Vincenzo De Luca and Tricia Sicard and J. V. Volavka and P{\'a}l Czobor and Brian B. Sheitman and Jean Pierre Lindenmayer and Leslie Citrome and J P Mcevoy and Jeffrey A. Lieberman and William Honer and James L Kennedy},
  journal={Neuroscience letters},
  year={2005},
  volume={379 2},
  pages={81-9}
}
The synaptosomal-associated protein of 25 kDa (SNAP-25) is an essential component of the core complex that mediates presynaptic vesicle trafficking. Thus, SNAP-25 is directly involved in the release of neurotransmitters. Quantitative alterations of SNAP-25 expression have been reported in brain regions and cerebrospinal fluid (CSF) of schizophrenics and in haloperidol treated rats. This observed altered expression may be influenced by genetic variants of SNAP-25. We hypothesized that… CONTINUE READING

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