The SNAP-25 gene is associated with cognitive ability: evidence from a family-based study in two independent Dutch cohorts

@article{Gosso2006TheSG,
  title={The SNAP-25 gene is associated with cognitive ability: evidence from a family-based study in two independent Dutch cohorts},
  author={Maria Florencia Gosso and Eco J. C. de Geus and Mj van Belzen and Tinca J. C. Polderman and Peter Heutink and Dorret I. Boomsma and Danielle Posthuma},
  journal={Molecular Psychiatry},
  year={2006},
  volume={11},
  pages={878-886}
}
The synaptosomal-associated protein of 25 kDa (SNAP-25) gene plays an integral role in synaptic transmission, and is differentially expressed in the mammalian brain in the neocortex, hippocampus, anterior thalamic nuclei, substantia nigra and cerebellar granular cells. Recent studies have suggested a possible involvement of SNAP-25 in learning and memory, both of which are key components of human intelligence. In addition, the SNAP-25 gene lies in a linkage area implicated previously in human… Expand
Common variants underlying cognitive ability: further evidence for association between the SNAP‐25 gene and cognition using a family‐based study in two independent Dutch cohorts
TLDR
The complete genomic region of the SNAP‐25 gene is examined to narrow down the location of causative genetic variant underlying the association, and two new variants in intron 1, close to the two previous reported variants showed association with variation in IQ phenotypes across both cohorts. Expand
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TLDR
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