The SMC5/6 complex maintains telomere length in ALT cancer cells through SUMOylation of telomere-binding proteins

@article{Potts2007TheSC,
  title={The SMC5/6 complex maintains telomere length in ALT cancer cells through SUMOylation of telomere-binding proteins},
  author={Patrick Ryan Potts and Hongtao Yu},
  journal={Nature Structural &Molecular Biology},
  year={2007},
  volume={14},
  pages={581-590}
}
Most cancer cells activate telomerase to elongate telomeres and achieve unlimited replicative potential. Some cancer cells cannot activate telomerase and use telomere homologous recombination (HR) to elongate telomeres, a mechanism termed alternative lengthening of telomeres (ALT). A hallmark of ALT cells is the recruitment of telomeres to PML bodies (termed APBs). Here, we show that the SMC5/6 complex localizes to APBs in ALT cells and is required for targeting telomeres to APBs. The MMS21… CONTINUE READING
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