The SLIT-ROBO pathway: a regulator of cell function with implications for the reproductive system.

@article{Dickinson2010TheSP,
  title={The SLIT-ROBO pathway: a regulator of cell function with implications for the reproductive system.},
  author={Rachel Emma Dickinson and William Colin Duncan},
  journal={Reproduction},
  year={2010},
  volume={139 4},
  pages={
          697-704
        }
}
The secreted SLIT glycoproteins and their Roundabout (ROBO) receptors were originally identified as important axon guidance molecules. They function as a repulsive cue with an evolutionarily conserved role in preventing axons from migrating to inappropriate locations during the assembly of the nervous system. In addition the SLIT-ROBO interaction is involved in the regulation of cell migration, cell death and angiogenesis and, as such, has a pivotal role during the development of other tissues… CONTINUE READING

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