The SLC30 family of zinc transporters - a review of current understanding of their biological and pathophysiological roles.

@article{Huang2013TheSF,
  title={The SLC30 family of zinc transporters - a review of current understanding of their biological and pathophysiological roles.},
  author={Liping Huang and Surapun Tepaamorndech},
  journal={Molecular aspects of medicine},
  year={2013},
  volume={34 2-3},
  pages={548-60}
}
Two families of zinc (Zn(2 +)) transporters are involved in zinc homeostasis in the body, SLC30 (ZnT, zinc transporter) and SLC39 (ZIP, Zinc(Zn(2+))-Iron(Fe(2+)) Permease). The two zinc transporter family members function in opposite directions to maintain cellular zinc homeostasis. ZnT proteins contribute to the cytoplasmic zinc balance by exporting zinc out to the extracellular space or by sequestrating cytoplasmic zinc into intracellular compartments when cellular zinc levels are elevated… CONTINUE READING
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