The SK2-Long Isoform Directs Synaptic Localization and Function of SK2-containing channels

  title={The SK2-Long Isoform Directs Synaptic Localization and Function of SK2-containing channels},
  author={Duane Allen and Chris T. Bond and Raphael Luj{\'a}n and Carmen Ballesteros-Merino and Mike Lin and Kang Wang and Nathan J Klett and Masahiko Watanabe and Ryuichi Shigemoto and Robert W. Stackman and James Maylie and John P Adelman},
  booktitle={Nature Neuroscience},
SK2-containing channels are expressed in the postsynaptic density (PSD) of dendritic spines on mouse hippocampal area CA1 pyramidal neurons and influence synaptic responses, plasticity and learning. The Sk2 gene (also known as Kcnn2) encodes two isoforms that differ only in the length of their N-terminal domains. SK2-long (SK2-L) and SK2-short (SK2-S) are coexpressed in CA1 pyramidal neurons and likely form heteromeric channels. In mice lacking SK2-L (SK2-S only mice), SK2-S–containing channels… CONTINUE READING


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