The SK2-Long Isoform Directs Synaptic Localization and Function of SK2-containing channels

@inproceedings{Allen2011TheSI,
  title={The SK2-Long Isoform Directs Synaptic Localization and Function of SK2-containing channels},
  author={Duane Allen and Chris T. Bond and Raphael Luj{\'a}n and Carmen Ballesteros-Merino and Mike Lin and Kang Wang and Nathan J Klett and Masahiko Watanabe and Ryuichi Shigemoto and Robert W. Stackman and James Maylie and John P Adelman},
  booktitle={Nature Neuroscience},
  year={2011}
}
SK2-containing channels are expressed in the postsynaptic density (PSD) of dendritic spines on mouse hippocampal area CA1 pyramidal neurons and influence synaptic responses, plasticity and learning. The Sk2 gene (also known as Kcnn2) encodes two isoforms that differ only in the length of their N-terminal domains. SK2-long (SK2-L) and SK2-short (SK2-S) are coexpressed in CA1 pyramidal neurons and likely form heteromeric channels. In mice lacking SK2-L (SK2-S only mice), SK2-S–containing channels… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 24 extracted citations

Dendritic spines: the locus of structural and functional plasticity.

Physiological reviews • 2014
View 20 Excerpts
Highly Influenced

Small-conductance calcium-activated potassium type 2 channels (SK2, KCa2.2) in human brain

Brain Structure and Function • 2016
View 6 Excerpts
Highly Influenced

KCa2 channel localization and regulation in the axon initial segment.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 2018
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-10 of 28 references

Coupled activity-dependent trafficking of synaptic SK2 channels and AMPA receptors.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2010

Similar Papers

Loading similar papers…