The SIRT2 Polymorphism rs10410544 and Risk of Alzheimer’s Disease: A Meta-analysis

  title={The SIRT2 Polymorphism rs10410544 and Risk of Alzheimer’s Disease: A Meta-analysis},
  author={Wenjin Wei and Xiupeng Xu and Hailin Li and Yaxuan Zhang and Dongfeng Han and Yingyi Wang and Wei Yan and Xiefeng Wang and Junxia Zhang and Ning Liu and Yongping You},
  journal={NeuroMolecular Medicine},
Previous studies have reported an association between human sirtuins’ single-nucleotide polymorphisms (SNPs) and Alzheimer’s disease (AD) susceptibility in the apolipoprotein E (APOE) ε4-negative population, although the findings are inconsistent. To obtain a more precise estimation of this relationship, we conducted a meta-analysis to assess the association between the rs10410544 C/T polymorphism of SIRT2 and the risk of AD with APOE ε4 status. We searched all relevant PubMed publications and… CONTINUE READING
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