The SIRT1 Modulators AROS and DBC1 Regulate HSF1 Activity and the Heat Shock Response

@inproceedings{Raynes2013TheSM,
  title={The SIRT1 Modulators AROS and DBC1 Regulate HSF1 Activity and the Heat Shock Response},
  author={Rachel Raynes and Kathleen M. Pombier and Kevin K. Nguyen and Jessica Brunquell and Jamie E. Mendez and Sandy D Westerheide},
  booktitle={PloS one},
  year={2013}
}
The heat shock response, the cellular response to protein damaging stress, is critical in maintaining proteostasis. The heat shock response is regulated by the transcription factor HSF1, which is activated upon heat shock and other stresses to induce the expression of molecular chaperones. SIRT1 has previously been shown to activate HSF1 by deacetylating it, leading to increased DNA binding ability. We have investigated how the heat shock response may be controlled by factors influencing SIRT1… CONTINUE READING