The SIGLEC14 null allele is associated with Mycobacterium tuberculosis- and BCG-induced clinical and immunologic outcomes.

@article{Graustein2017TheSN,
  title={The SIGLEC14 null allele is associated with Mycobacterium tuberculosis- and BCG-induced clinical and immunologic outcomes.},
  author={Andrew D Graustein and David J. Horne and Jerry J. Fong and Flavio Schwarz and Heather C. Mefford and Glenna J. Peterson and Richard Dean Wells and Munyaradzi Nyasha Musvosvi and Muki Shehu Shey and Willem A Hanekom and Mark Hatherill and Thomas J Scriba and Nguyen Thuy Thuong Thuong and Nguyễn Thị Thanh Mai and Maxine Caws and Nguyen Duc Bang and Sarah J Dunstan and Guy E Thwaites and Ajit Varki and Takashi Angata and Thomas R Hawn},
  journal={Tuberculosis},
  year={2017},
  volume={104},
  pages={
          38-45
        }
}
Humans exposed to Mycobacterium tuberculosis (Mtb) have variable susceptibility to tuberculosis (TB) and its outcomes. Siglec-5 and Siglec-14 are members of the sialic-acid binding lectin family that regulate immune responses to pathogens through inhibitory (Siglec-5) and activating (Siglec-14) domains. The SIGLEC14 coding sequence is deleted in a high proportion of individuals, placing a SIGLEC5-like gene under the expression of the SIGLEC14 promoter (the SIGLEC14 null allele) and causing… CONTINUE READING
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CP Simmons, GE Thwaites, +3 authors NT Dung
  • Graustein et al. / Tuberculosis
  • 2017
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