The SH3 domain of Eps8 exists as a novel intertwined dimer

@article{Kishan1997TheSD,
  title={The SH3 domain of Eps8 exists as a novel intertwined dimer},
  author={K. V. Radha Kishan and Giorgio Scita and William T. Wong and Pier Paolo Di Fiore and Marcia Elizabeth Newcomer},
  journal={Nature Structural Biology},
  year={1997},
  volume={4},
  pages={739-743}
}
SH3 domains are structurally well-characterized as monomeric modular units of protein structure that mediate protein–protein recognition in numerous signal transduction proteins. The X-ray crystallographic structure of the Eps8 SH3 domain reveals a novel variation of the canonical SH3 fold: the SH3 domain from Eps8 is a dimer formed by strand interchange. In addition, co-immunoprecipitation experiments show that intact Eps8 is multimeric in vivo. Hence, the SH3 domain of Eps8 may represent a… CONTINUE READING
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