Corpus ID: 45594432

The SH 3 Domain of the Saccharomyces cerevisiae Peroxisomal Membrane Protein Pex 13 p Functions as a Docking Site for Pex 5 p , a Mobile Receptor for the Import of PTSl-containing Proteins

@inproceedings{Elgersma2002TheS3,
  title={The SH 3 Domain of the Saccharomyces cerevisiae Peroxisomal Membrane Protein Pex 13 p Functions as a Docking Site for Pex 5 p , a Mobile Receptor for the Import of PTSl-containing Proteins},
  author={Y. Elgersma and L. Kwast and T. Voorn-Brouwer and M. Berg and B. Metzig and T. America and H. Tabak and B. Distel},
  year={2002}
}
  • Y. Elgersma, L. Kwast, +5 authors B. Distel
  • Published 2002
  • We identified a Saccharomyces cerevisiae peroxisomal membrane protein, Pexl3p, that is essential for protein import. A point mutation in the COOHterminal Src homology 3 (SH3) domain of Pexl3p inactivated the protein but did not affect its membrane targeting. A two-hybrid screen with the SH3 domain of Pexl3p identified Pex5p, a receptor for proteins with a type I peroxisomal targeting signal (PTS1), as its ligand. Pexl3p SH3 interacted specifically with Pex5p in vitro. We determined, furthermore… CONTINUE READING
    21 Citations

    Figures and Tables from this paper

    Pex14p, more than just a docking protein.
    • 73
    • PDF
    In silicio search for genes encoding peroxisomal proteins in Saccharomyces cerevisiae
    • 15
    Pex10p links the ubiquitin conjugating enzyme Pex4p to the protein import machinery of the peroxisome
    • 82
    • PDF
    Biogenesis of peroxisomes
    • 126
    Studies on peroxisome biogenesis
    • 2
    • PDF

    References

    SHOWING 1-10 OF 71 REFERENCES
    Identification and Characterization of the Putative Human Peroxisomal C-terminal Targeting Signal Import Receptor (*)
    • 164
    • PDF
    PAS10 is a tetratricopeptide-repeat protein that is essential for the import of most matrix proteins into peroxisomes of Saccharomyces cerevisiae.
    • 220
    • PDF
    Differential protein import deficiencies in human peroxisome assembly disorders
    • 122
    • PDF
    An oligomeric protein is imported into peroxisomes in vivo
    • 345
    • PDF