The SH 2-containing tyrosine phosphatase corkscrew is required during signaling by sevenless , Ras 1 and Raf

@inproceedings{Allard1996TheS2,
  title={The SH 2-containing tyrosine phosphatase corkscrew is required during signaling by sevenless , Ras 1 and Raf},
  author={John D. Allard and Henry C. Chang and Ronald Herbst and Helen McNeill and Michael A. Simon},
  year={1996}
}
The sevenless gene encodes a receptor tyrosine kinase which is required for the development of the R7 photoreceptor cell in each ommatidium of the Drosophila eye. We have previously used a sensitized genetic screen to identify mutations, designated Enhancers of sevenless (E(sev)), which affect genes that encode components of the sevenless signaling pathway. Here, we report that one of these mutations, E(sev)1Ae0P is a dominantly inhibiting allele of corkscrew, which encodes an SH2 domain… CONTINUE READING

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