The SERPINE2 gene is associated with chronic obstructive pulmonary disease.

@article{DeMeo2006TheSG,
  title={The SERPINE2 gene is associated with chronic obstructive pulmonary disease.},
  author={Dawn L. DeMeo and Thomas J. Mariani and Christoph Lange and Sorachai Srisuma and Augusto A Litonjua and Juan C. Celed{\'o}n and Stephen L. Lake and John J. Reilly and Harold A Chapman and Brigham H. Mecham and Kathleen J. Haley and Jody Senter Sylvia and David W Sparrow and Avrum Spira and Jennifer Beane and Victor M. Pinto-Plata and Frank E. Speizer and Steven D Shapiro and Scott T. Weiss and Edwin K. Silverman},
  journal={American journal of human genetics},
  year={2006},
  volume={78 2},
  pages={
          253-64
        }
}
Chronic obstructive pulmonary disease (COPD) is a complex human disease likely influenced by multiple genes, cigarette smoking, and gene-by-smoking interactions, but only severe alpha 1-antitrypsin deficiency is a proven genetic risk factor for COPD. Prior linkage analyses in the Boston Early-Onset COPD Study have demonstrated significant linkage to a key intermediate phenotype of COPD on chromosome 2q. We integrated results from murine lung development and human COPD gene-expression microarray… CONTINUE READING
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