The SEEKING mind: Primal neuro-affective substrates for appetitive incentive states and their pathological dynamics in addictions and depression
@article{Alcaro2011TheSM, title={The SEEKING mind: Primal neuro-affective substrates for appetitive incentive states and their pathological dynamics in addictions and depression}, author={Antonio Alcaro and Jaak Panksepp}, journal={Neuroscience \& Biobehavioral Reviews}, year={2011}, volume={35}, pages={1805-1820} }
183 Citations
The SEEKING Drive and Its Fixation: A Neuro-Psycho-Evolutionary Approach to the Pathology of Addiction
- PsychologyFrontiers in Human Neuroscience
- 2021
From a neuro-psycho-evolutionary point of view, the predisposition to develop addictive behavior can be attributed to a loss of “functional autonomy” of the SEEKING/Explorative disposition.
An innate brainstem self-other system involving orienting, affective responding, and polyvalent relational seeking: Some clinical implications for a "Deep Brain Reorienting" trauma psychotherapy approach.
- Psychology, BiologyMedical hypotheses
- 2019
Thalamocortical integration of instrumental learning and performance and their disintegration in addiction
- Psychology, BiologyBrain Research
- 2015
The Bed Nucleus of the Stria Terminalis, Homeostatic Satiety, and Compulsions: What Can We Learn From Polydipsia?
- Psychology, BiologyFront. Behav. Neurosci.
- 2019
Polydipsia (or non-regulatory water drinking) is used to describe candidate neural substrates of compulsivity and it is postulated that aberrant neuroplasticity within cortically projecting structures and circuits that encode homeostatic emotions underlie compulsive drinking.
The “Instinct” of Imagination. A Neuro-Ethological Approach to the Evolution of the Reflective Mind and Its Application to Psychotherapy
- PsychologyFront. Hum. Neurosci.
- 2019
The intrinsic self-referential dynamism of the “brainmind” originated from REM sleep arousal and then evolved in the resting-state activity of a complex of cortico-limbic midline brain structures (CMS), also called Default Mode Network (DMN).
Sleep and dreaming are for important matters
- Psychology, BiologyFront. Psychol.
- 2013
It is suggested that, via the activation of emotional/motivational circuits, sleep and dreaming may offer a neurobehavioral substrate for the offline reprocessing of emotions, associative learning, and exploratory behaviors, resulting in improved memory organization, waking emotion regulation, social skills, and creativity.
Orquestic regulation of neurotransmitters on reward-seeking behavior
- Biology, PsychologyInternational archives of medicine
- 2014
Current evidence on the orquestic regulation of different neurotranmitters on reward-seeking behavior and its potential effect on drug addiction is discussed.
The roles of the reward system in sleep and dreaming
- Psychology, BiologyNeuroscience & Biobehavioral Reviews
- 2012
Deep brain stimulation of the “medial forebrain bundle”: a strategy to modulate the reward system and manage treatment-resistant depression
- Psychology, BiologyMolecular Psychiatry
- 2021
Major depression is discussed in the context of being a disorder dependent on multiple relevant networks, the pathological performance of which is responsible for the manifestation of various symptoms of the disease which extend into emotional, motivational, physiological, and also cognitive domains of daily living.
The role of the basal ganglia in motivated behavior
- Biology, PsychologyReviews in the neurosciences
- 2012
Dopamine release in response to salient USs and to CSs with incentive salience increases the signal-to-noise ratio of corticostriatal neurotransmission, thus ‘energizing’ the performance of selected actions.
References
SHOWING 1-10 OF 314 REFERENCES
Behavioral functions of the mesolimbic dopaminergic system: An affective neuroethological perspective
- Psychology, BiologyBrain Research Reviews
- 2007
Affective neuroscientific and neuropsychoanalytic approaches to two intractable psychiatric problems: Why depression feels so bad and what addicts really want
- PsychologyNeuroscience & Biobehavioral Reviews
- 2011
Dynamics of neuronal circuits in addiction: reward, antireward, and emotional memory.
- Psychology, BiologyPharmacopsychiatry
- 2009
It is argued that brain stress systems activated by the motivational consequences of drug withdrawal can not only form the basis for negative reinforcement that drives drug seeking, but also potentiate associative mechanisms that perpetuate the emotional state and help drive the allostatic state of addiction.
Neurobiology of the structure of personality: Dopamine, facilitation of incentive motivation, and extraversion
- Psychology, BiologyBehavioral and Brain Sciences
- 1999
The animal evidence suggests that there are three neurodevelopmental sources of individual differences in dopamine: genetic, "experiences-expectant," and "experience-dependent." Individual differences in serotonin promote variation in the heterosynaptic plasticity that enhances the connection between incentive context and incentive motivation and behavior.
The neurobiology of positive emotions
- Biology, PsychologyNeuroscience & Biobehavioral Reviews
- 2006
Affective consciousness: Core emotional feelings in animals and humans
- Psychology, BiologyConsciousness and Cognition
- 2005
The role of brain emotional systems in addictions: a neuro-evolutionary perspective and new 'self-report' animal model.
- Psychology, BiologyAddiction
- 2002
It is illustrated how a mammalian model of emotion (i.e. rodent ultrasonic vocalizations) may enable scientists to predict drug-related phenomena such as abuse potential, anatomical location of mediating neural substrates, and the psychological impact of withdrawal.
Cross-species affective functions of the medial forebrain bundle—Implications for the treatment of affective pain and depression in humans
- PsychologyNeuroscience & Biobehavioral Reviews
- 2011
Neurobiological mechanisms for opponent motivational processes in addiction
- Biology, PsychologyPhilosophical Transactions of the Royal Society B: Biological Sciences
- 2008
The combination of loss of reward function and recruitment of brain stress systems provides a powerful neurochemical basis for the long hypothesized opponent motivational processes responsible for the negative reinforcement driving addiction.
d-amphetamine stimulates unconditioned exploration/approach behaviors in crayfish: Towards a conserved evolutionary function of ancestral drug reward
- Biology, PsychologyPharmacology Biochemistry and Behavior
- 2011