The SDF-1-CXCR4 axis stimulates VEGF secretion and activates integrins but does not affect proliferation and survival in lymphohematopoietic cells.

@article{Kijowski2001TheSA,
  title={The SDF-1-CXCR4 axis stimulates VEGF secretion and activates integrins but does not affect proliferation and survival in lymphohematopoietic cells.},
  author={Jacek Kijowski and Monika Baj-Krzyworzeka and Marcin Majka and Ryan G Reca and Leah A Marquez and Melpo Christofidou-Solomidou and Anna Janowska-Wieczorek and Mariusz Z Ratajczak},
  journal={Stem cells},
  year={2001},
  volume={19 5},
  pages={453-66}
}
To better define the role HIV-related chemokine receptor-chemokine axes play in human hematopoiesis, we investigated the function of the CXCR4 and CCR5 receptors in human myeloid, T- and B-lymphoid cell lines selected for the expression of these receptors (CXCR4(+), CXCR4(+) CCR5(+), and CCR5(+) cell lines). We evaluated the phosphorylation of MAPK p42/44, AKT, and STAT proteins and examined the ability of the ligands for these receptors (stromal-derived factor-1 [SDF-1] and macrophage… CONTINUE READING

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