The SCL gene product is regulated by and differentially regulates cytokine responses during myeloid leukemic cell differentiation.

@article{Tanigawa1993TheSG,
  title={The SCL gene product is regulated by and differentially regulates cytokine responses during myeloid leukemic cell differentiation.},
  author={Takahiko Tanigawa and N Elwood and Donald Metcalf and Dale Cary and E. Deluca and Nicos A. Nicola and C. G. Begley},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1993},
  volume={90 16},
  pages={7864-8}
}
Differentiation induction in murine M1 leukemia cells by interleukin 6 (IL-6), leukemia inhibitory factor (LIF), and oncostatin M (OSM) is postulated to occur via a common receptor chain, gp130. In this study, growth factor-induced differentiation of M1 cells was accompanied by a late and persistent decrease in levels of mRNA and protein for a helix-loop-helix transcription factor, the SCL gene product. To evaluate whether reduced SCL expression was instrumental in monocyte differentiation, an… CONTINUE READING

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