The SCID/Beige mouse as a model to investigate protection against Yersinia pestis.

@article{Green1999TheSM,
  title={The SCID/Beige mouse as a model to investigate protection against Yersinia pestis.},
  author={Michael Green and Debbie Rogers and Paul F. Russell and Anthony J Stagg and David L. Bell and Stephen M Eley and Richard W. Titball and Ethel D. Williamson},
  journal={FEMS immunology and medical microbiology},
  year={1999},
  volume={23 2},
  pages={
          107-13
        }
}
In this study, we have shown that severe combined immunodeficient/beige mice reconstituted with hyperimmune Balb/c lymphocytes can be used as a model to demonstrate adoptive and passive protection against plague infection. Reconstitution of severe combined immunodeficient/beige mice was successful in nine out of ten mice as demonstrated by spleen colonisation and sustained circulating immunoglobulin titres. Furthermore, an increase in antibody titre was evident after a booster immunisation of… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 23 extracted citations

Similar Papers

Loading similar papers…