The SCFSlimb E3 ligase complex regulates asymmetric division to inhibit neuroblast overgrowth.

@article{Li2014TheSE,
  title={The SCFSlimb E3 ligase complex regulates asymmetric division to inhibit neuroblast overgrowth.},
  author={Song Li and Cheng Jian Wang and Edwin Sandanaraj and Sherry S Aw and Chwee Tat Koe and Jack Jing Lin Wong and Fengwei Yu and Beng Ti Ang and Carol Soo-Leng Tang and Hongyan Wang},
  journal={EMBO reports},
  year={2014},
  volume={15 2},
  pages={165-74}
}
Drosophila larval brain neuroblasts divide asymmetrically to balance between self-renewal and differentiation. Here, we demonstrate that the SCF(Slimb) E3 ubiquitin ligase complex, which is composed of Cul1, SkpA, Roc1a and the F-box protein Supernumerary limbs (Slimb), inhibits ectopic neuroblast formation and regulates asymmetric division of neuroblasts… CONTINUE READING