The SCF ubiquitin ligase: insights into a molecular machine

  title={The SCF ubiquitin ligase: insights into a molecular machine},
  author={Timothy Cardozo and Michele Pagano},
  journal={Nature Reviews Molecular Cell Biology},
Ubiquitin ligases are well suited to regulate molecular networks that operate on a post-translational timescale. The F-box family of proteins — which are the substrate-recognition components of the Skp1–Cul1–F-box-protein (SCF) ubiquitin ligase — are important players in many mammalian functions. Here we explore a unifying and structurally detailed view of SCF-mediated proteolytic control of cellular processes that has been revealed by recent studies. 
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