The SCF ubiquitin ligase: an extended look.

  title={The SCF ubiquitin ligase: an extended look.},
  author={Peter Kent Jackson and Adam G. Eldridge},
  journal={Molecular cell},
  volume={9 5},
The SCF E3 ubiquitin ligases select specific proteins for ubiquitination (and typically destruction) by coupling variable adaptor (F box) proteins that bind protein substrates to a conserved catalytic engine containing a cullin, Cul1, and the Rbx1/Roc1 RING finger protein. A new crystal structure of the SCF(Skp2) ubiquitin ligase shows the molecular organization of this complex and raises important questions as to how substrate ubiquitination is accomplished. 

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