The SCF-type E3 Ubiquitin Ligases as Cancer Targets.

  title={The SCF-type E3 Ubiquitin Ligases as Cancer Targets.},
  author={Kyoko Kitagawa and Masatoshi Kitagawa},
  journal={Current cancer drug targets},
  volume={16 2},
The ubiquitin system controls protein stability and function. F-box proteins form SCF (SKP1-Cullin1-F-box protein)-type ubiquitin (E3) ligases to selectively target their substrates for degradation via the ubiquitin-proteasome pathway. Here, we review F-box proteins associated with cancer development. S-phase kinase-associated protein 2 (SKP2) (also known as FBXL1) is often overexpressed in human cancers, and functions as an oncogenic E3 ligase to degrade tumor suppressor gene products… CONTINUE READING