The SCF/Slimb Ubiquitin Ligase Limits Centrosome Amplification through Degradation of SAK/PLK4

  title={The SCF/Slimb Ubiquitin Ligase Limits Centrosome Amplification through Degradation of SAK/PLK4},
  author={In{\^e}s Cunha-Ferreira and A. Rodrigues-Martins and Ines Bento and M. Riparbelli and W. Zhang and E. Laue and G. Callaini and D. Glover and M. Bettencourt-Dias},
  journal={Current Biology},
  • Inês Cunha-Ferreira, A. Rodrigues-Martins, +6 authors M. Bettencourt-Dias
  • Published 2009
  • Biology, Medicine
  • Current Biology
  • Centrioles are essential for the formation of microtubule-derived structures, including cilia and centrosomes. Abnormalities in centrosome number and structure occur in many cancers and are associated with genomic instability. In most dividing animal cells, centriole formation is coordinated with DNA replication and is highly regulated such that only one daughter centriole forms close to each mother centriole. Centriole formation is triggered and dependent on a conserved kinase, SAK/PLK4… CONTINUE READING
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