The SCF/Slimb Ubiquitin Ligase Limits Centrosome Amplification through Degradation of SAK/PLK4

@article{CunhaFerreira2009TheSU,
  title={The SCF/Slimb Ubiquitin Ligase Limits Centrosome Amplification through Degradation of SAK/PLK4},
  author={In{\^e}s Cunha-Ferreira and Ana Rodrigues-Martins and In{\^e}s Mariana Pereira Bento and Maria Riparbelli and Wei Zhang and Ernest D. Laue and Giuliano Callaini and David M Glover and M{\'o}nica Bettencourt-Dias},
  journal={Current Biology},
  year={2009},
  volume={19},
  pages={43-49}
}
Centrioles are essential for the formation of microtubule-derived structures, including cilia and centrosomes. Abnormalities in centrosome number and structure occur in many cancers and are associated with genomic instability. In most dividing animal cells, centriole formation is coordinated with DNA replication and is highly regulated such that only one daughter centriole forms close to each mother centriole. Centriole formation is triggered and dependent on a conserved kinase, SAK/PLK4… CONTINUE READING

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