The SCF/KIT pathway plays a critical role in the control of normal human melanocyte homeostasis.

@article{Grichnik1998TheSP,
  title={The SCF/KIT pathway plays a critical role in the control of normal human melanocyte homeostasis.},
  author={James M. Grichnik and James Burch and J Burchette and Christopher Shea},
  journal={The Journal of investigative dermatology},
  year={1998},
  volume={111 2},
  pages={233-8}
}
During development, the interaction of stem cell factor (SCF) with its receptor, KIT, is critical for the survival of melanocytes. Limited in vivo human studies have suggested a possible activating role of SCF on adult human melanocytes. In order to study the impact of this pathway on normal melanocyte homeostasis, human skin xenografts were treated with serial injections of recombinant human SCF or a KIT-inhibitory antibody (K44.2). On histologic evaluation, SCF injection increased, whereas… CONTINUE READING